Manioc : Portail | resultats 1 - 10 pour la recherche: Shepherd, Bryan E

Six months in the West Indies, in 1825
Auteur(s) : Coleridge, Henry Nelson (1798-1843)
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Heterogeneity in outcomes of treated HIV-positive patients in Europe and North America: relation with patient and cohort characteristics.
Auteur(s) : May, Margaret T Hogg, Robert S Justice, Amy C Shepherd, Bryan E Costagliola, Dominique Ledergerber, Bruno Thiébaut, Rodolphe Gill, M John
Auteurs secondaires : Epidémiologie, stratégies thérapeutiques et virologie cliniques dans l'infection à VIH ; Université Pierre et Marie Curie - Paris 6 (UPMC) - Institut National de la Santé et de la Recherche Médicale (INSERM) Epidémiologie et Biostatistique [Bordeaux] ; Université Bordeaux Segalen - Bordeaux 2 - Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED) - Institut National de la Santé et de la Recherche Médicale (INSERM) Population Sciences ; University College of London [London] (UCL) Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) Antiretroviral Therapy Cohort Collaboration (ART-CC)

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
BACKGROUND: HIV cohort collaborations, which pool data from diverse patient cohorts, have provided key insights into outcomes of antiretroviral therapy (ART). However, the extent of, and reasons for, between-cohort heterogeneity in rates of AIDS and mortality are unclear. METHODS: We obtained data on adult HIV-positive patients who started ART from 1998 without a previous AIDS diagnosis from 17 cohorts in North America and Europe. Patients were followed up from 1 month to 2 years after starting ART. We examined between-cohort heterogeneity in crude and adjusted (age, sex, HIV transmission risk, year, CD4 count and HIV-1 RNA at start of ART) rates of AIDS and mortality using random-effects meta-analysis and meta-regression. RESULTS: During 61 520 person-years, 754/38 706 (1.9%) patients died and 1890 (4.9%) progressed to AIDS. Between-cohort variance in mortality rates was reduced from 0.84 to 0.24 (0.73 to 0.28 for AIDS rates) after adjustment for patient characteristics. Adjusted mortality rates were inversely associated with cohorts' estimated completeness of death ascertainment [excellent: 96-100%, good: 90-95%, average: 75-89%; mortality rate ratio 0.66 (95% confidence interval 0.46-0.94) per category]. Mortality rate ratios comparing Europe with North America were 0.42 (0.31-0.57) before and 0.47 (0.30-0.73) after adjusting for completeness of ascertainment. CONCLUSIONS: Heterogeneity between settings in outcomes of HIV treatment has implications for collaborative analyses, policy and clinical care. Estimated mortality rates may require adjustment for completeness of ascertainment. Higher mortality rate in North American, compared with European, cohorts was not fully explained by completeness of ascertainment and may be because of the inclusion of more socially marginalized patients with higher mortality risk.
ISSN: 0300-5771

hal-00875138
https://hal.archives-ouvertes.fr/hal-00875138
DOI : 10.1093/ije/dys164
PUBMED : 23148105

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A voyage to the Demerary : containing a statistical account of the settlements there, and of those on the Essequebo, the Berbice, and others contiguous rivers of Guyana
Auteur(s) : Bolingbroke, Henry (1785-1855)
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Bibliographie d'histoire coloniale : 1900-1930
Auteur(s) : Martineau, Alfred (1859-1945) Roussier, Paul (1882-1965) Tramond, Joannès (1882-1935)
Auteurs secondaires : Congrès international d'histoire coloniale (1 ; 1931 ; Paris)
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Four years' residence in the West Indies
Auteur(s) : Bayley, Frederic William Naylor (1808-1853)
Auteurs secondaires : Haghe, Charles (1810-1888) Day, William (1797-1845)
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The history, civil and commercial, of the British colonies in the West Indies. Volume I
Auteur(s) : Edwards, Bryan (1743-1800)
Auteurs secondaires : Bartolozzi, Francesco (1727-1815) West, Benjamin (1738-1820) Milton, Thomas (1743?-1827)
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Six months in the West Indies
Auteur(s) : Coleridge, Henry Nelson (1798-1843)
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The West Indies in 1837; being the journal of a visit to Antigua, Montserrat, Dominica, St. Lucia, Barbados, and Jamaïca : undertaken for the purpose of ascertaining the actual condition of the negro population of those islands
Auteur(s) : Sturge, Joseph (1793-1859) Harvey, Thomas (1812-1884)
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Antigua and the Antiguans: a full account of the colony and its inhabitants from the time of the Caribs to the present day, interspersed with anecdotes and legends : also, an impartial view of slavery and the free labour systems, the statistics of the island, and biographical notices of the principal families, Volume 2
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England and the French Revolution 1789-1797
Auteur(s) : Laprade, William Thomas
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